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KMID : 0377619730250040453
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Korean Jungang Medical Journal
1973 Volume.25 No. 4 p.453 ~ p.455
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Therapeutic Effect of "Tinidazole" Against Giardia Lamblia
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崔源永/Choi, Won-Young
李玉蘭/李元求/이규면/朴定圭/李水月/Lee, Ok-Ran/Lee, Won-Koo/Lee, Kyu-Myon/Lim, Jung-Kyu/Lee, Soo Wol
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Abstract
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"Tinidazole a new antiflagellate drug, was given orally for 3-7 days to 99 children infected with G.lamblia. Stool examination for detection and evaluation of therapeutic on giardiasis were made by formaline-ether concentration techniques. The children were grouped according to doses and the duration of administration of the drug.
The results were summarized as follows;
1) Except 1 case out of 99 children, none of the children showed G. lamblia in the stool examination 2 weeks after administration of the drug, regardless of groups.
2) 4 weeks after administration of the drug, group A (10 mg per kg for 7 days) and group B (5 mg per kg for 7 days) children showed 100% of negative conversion, but group C (10 mg per kg for 5 days) children revealed 84.6% of negatives.
3) 6 months later, the negative conversion rates in groups A, B and C were reduced to 54.5%, 57. 1% and 50. 0% respectively.
4) Mild or transient side effects-nausea, abdominal pain, headache or fever and diarrhea were noted in 16 cases (27. 1%) out of 59 cases.
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